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Is the COL5A1 rs12722 gene polymorphism associated with running economy?

ABSTRACT: The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150) physically active young men performed the following tests: a) a maximal incremental treadmill test, b) two constant-speed running tests (10 km · h(-1)) and 12 km · h(-1)) to determine the running economy, and c) a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km · h(-1) (p = 0.232) and 12 km · h(-1) (p = 0.259). Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337). These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running.

SUBMITTER: Bertuzzi R

PROVIDER: S-EPMC4154741 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Is the COL5A1 rs12722 gene polymorphism associated with running economy?

Bertuzzi Rômulo R Pasqua Leonardo A LA Bueno Salomão S Lima-Silva Adriano Eduardo AE Matsuda Monique M Marquezini Monica M Saldiva Paulo H PH

PloS one 20140904 9

The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 pol ...[more]

PMID: 25188268

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Project description:BackgroundThe percentage of sustained maximal oxygen uptake and the running economy are important factors that determine the running success of endurance athletes. Running economy is defined as the oxygen uptake required to run at a given speed and depends on metabolic, cardiorespiratory, biomechanical, neuromuscular, and anthropometric factors. With regard to anthropometric characteristics, total body mass seems to be a crucial factor for the running economy. Moreover, neuromuscular components, especially knee muscular strength and the strength balance ratio, also seem to be critical for the running economy. In addition to knee muscle strength, hip muscle strength is also an important contributor to running performance on level or hilly ground. However, the relationship between running economy and the hip muscles is unknown. Thus the aim of the present study was to verify whether hip flexor and extensor isokinetic peak torque, the isokinetic strength balance ratio, total body mass and fat free mass were associated with running economy in both sexes and to compare sex differences in physical fitness and isokinetic strength characteristics.MethodsA total of 24 male (31.0 ± 7.7 years, 176.2 ± 7.3 cm, and 70.4 ± 8.4 kg) and 15 female (31.3 ± 6.7 years, 162.9 ± 3.9 cm, and 56.0 ± 5.3 kg) recreationally-trained endurance runners were recruited. Maximal oxygen uptake, running economy, conventional (concentric flexors-to-concentric extensors) and functional (concentric flexors-to-eccentric extensors) hip isokinetic strength balance ratios, peak torque of the hip flexor and extensor muscles, total body mass, and fat-free mass were measured. Running economy was assessed on two separate days by means of the energy running cost (Ec) using a motorized treadmill at 10.0 and 12.0 km h-1 (3% gradient) and 11.0 and 14.0 km h-1 (1% gradient).ResultsThe functional balance ratio was significantly and negatively associated with Ec at 11.0 (r = - 0.43, P = 0.04) and 12.0 km h-1 (r = - 0.65, P = 0.04) when using a 3% gradient in male runners. Considering muscular strength, male runners only showed a significant relationship between Ec (assessed at 12 km h-1 and a 3% gradient) and peak torque for extensor muscle eccentric action (r = 0.72, P = 0.04). For female runners, only peak torque relative to total body mass for extensor muscles (180° s-1) was positively associated with Ec when assessed at 10 km h-1 using a 3% gradient (r = 0.59, P = 0.03). No significant relationships were found between Ec and total body mass or fat-free mass.DiscussionGiven that the functional balance ratio was associated with a better Ec, coaches and athletes should consider implementing a specific strengthening program for hip flexor muscles to increase the functional ratio.

Project description:BACKGROUND:Poor joint flexibility has been repeatedly proposed as a risk factor for muscle injury. The C-to-T polymorphism (rs12722) in the 3'-untranslated region of the collagen type V ?1 chain gene (COL5A1) is reportedly associated with joint flexibility. Flexibility of a normal joint is largely determined by passive muscle stiffness, which is influenced by intramuscular collagenous connective tissues including type V collagen. The present study aimed to test the hypothesis that the COL5A1 rs12722 polymorphism influences joint flexibility via passive muscle stiffness, and is accordingly associated with the incidence of muscle injury. METHODS:In Study 1, we examined whether the rs12722 polymorphism is associated with joint flexibility and passive muscle stiffness in 363 healthy young adults. Joint flexibility was evaluated by passive straight-leg-raise and sit-and-reach tests, and passive muscle stiffness was measured using ultrasound shear wave elastography. In Study 2, the association of the rs12722 polymorphism with sports-related muscle injury was assessed in 1559 Japanese athletes. Muscle injury history and severity were assessed by a questionnaire. In both Study 1 and Study 2, the rs12722 C-to-T polymorphism in the COL5A1 was determined using the TaqMan SNP Genotyping Assay. RESULTS:Study 1 revealed that the rs12722 polymorphism had no significant effect on range of motion in passive straight-leg-raise and sit-and-reach tests. Furthermore, there was no significant difference in passive muscle stiffness of the hamstring among the rs12722 genotypes. In Study 2, rs12722 genotype frequencies did not differ between the muscle injury and no muscle injury groups. Moreover, no association was observed between rs12722 polymorphism and severity of muscle injury. CONCLUSIONS:The present study does not support the view that COL5A1 rs12722 polymorphism has a role as a risk factor for sports-related muscle injury, or that it is a determinant for passive muscle stiffness in a Japanese population.

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Is the COL5A1 rs12722 gene polymorphism associated with running economy?

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Is the COL5A1 rs12722 gene polymorphism associated with running economy?

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