Ontology highlight
ABSTRACT:
SUBMITTER: Yao K
PROVIDER: S-EPMC4154980 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Yao Ke K Chen Hanyong H Liu Kangdong K Langfald Alyssa A Yang Ge G Zhang Yi Y Yu Dong Hoon DH Kim Myoung Ok MO Lee Mee-Hyun MH Li Haitao H Bae Ki Beom KB Kim Hong-Gyum HG Ma Wei-Ya WY Bode Ann M AM Dong Ziming Z Dong Zigang Z
Cancer prevention research (Philadelphia, Pa.) 20140703 9
Solar UV (SUV) irradiation is a major factor in skin carcinogenesis, the most common form of cancer in the United States. The MAPK cascades are activated by SUV irradiation. The 90 kDa ribosomal S6 kinase (RSK) and mitogen and stress-activated protein kinase (MSK) proteins constitute a family of protein kinases that mediate signal transduction downstream of the MAPK cascades. In this study, phosphorylation of RSK and MSK1 was upregulated in human squamous cell carcinoma (SCC) and SUV-treated mou ...[more]