Ontology highlight
ABSTRACT:
SUBMITTER: Fleischhauer K
PROVIDER: S-EPMC4154997 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Fleischhauer K K Fernandez-Viña M A MA Wang T T Haagenson M M Battiwalla M M Baxter-Lowe L A LA Ciceri F F Dehn J J Gajewski J J Hale G A GA Heemskerk M B A MB Marino S R SR McCarthy P L PL Miklos D D Oudshoorn M M Pollack M S MS Reddy V V Senitzer D D Shaw B E BE Waller E K EK Lee S J SJ Spellman S R SR
Bone marrow transplantation 20140623 9
HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each other. Non-permissive unrelated donor (UD)-recipient HLA-DPB1 mismatches across three different T-cell epitope (TCE) groups are associated with increased mortality after hematopoietic SCT (HCT), but the role of HLA-DPA1 is unclear. We studied 1281 onco-hematologic patients after 10/10 HLA-matched UD-HCT facilitated by the National Marrow Don ...[more]