Ontology highlight
ABSTRACT:
SUBMITTER: Lee YH
PROVIDER: S-EPMC4155016 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Lee Yun-Han YH Seo Daekwan D Choi Kyung-Ju KJ Andersen Jesper B JB Won Min-Ah MA Kitade Mitsuteru M Gómez-Quiroz Luis E LE Judge Adam D AD Marquardt Jens U JU Raggi Chiara C Conner Elizabeth A EA MacLachlan Ian I Factor Valentina M VM Thorgeirsson Snorri S SS
Cancer research 20140623 17
Histone deacetylase 2 (HDAC2) is a chromatin modifier involved in epigenetic regulation of cell cycle, apoptosis, and differentiation that is upregulated commonly in human hepatocellular carcinoma (HCC). In this study, we show that specific targeting of this HDAC isoform is sufficient to inhibit HCC progression. siRNA-mediated silencing of HDAC inhibited HCC cell growth by blocking cell-cycle progression and inducing apoptosis. These effects were associated with deregulation of HDAC-regulated ge ...[more]