Ontology highlight
ABSTRACT:
SUBMITTER: Josson S
PROVIDER: S-EPMC4155061 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Josson Sajni S Gururajan Murali M Hu Peizhen P Shao Chen C Chu GinaChia-Yi GY Zhau Haiyen E HE Liu Chunyan C Lao Kaiqin K Lu Chia-Lun CL Lu Yi-Tsung YT Lichterman Jake J Nandana Srinivas S Li Quanlin Q Rogatko Andre A Berel Dror D Posadas Edwin M EM Fazli Ladan L Sareen Dhruv D Chung Leland W K LW
Clinical cancer research : an official journal of the American Association for Cancer Research 20140624 17
<h4>Purpose</h4>miR-409-3p/-5p is a miRNA expressed by embryonic stem cells, and its role in cancer biology and metastasis is unknown. Our pilot studies demonstrated elevated miR-409-3p/-5p expression in human prostate cancer bone metastatic cell lines; therefore, we defined the biologic impact of manipulation of miR-409-3p/-5p on prostate cancer progression and correlated the levels of its expression with clinical human prostate cancer bone metastatic specimens.<h4>Experimental design</h4>miRNA ...[more]