Ontology highlight
ABSTRACT:
SUBMITTER: Yizhar O
PROVIDER: S-EPMC4155501 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Yizhar Ofer O Fenno Lief E LE Prigge Matthias M Schneider Franziska F Davidson Thomas J TJ O'Shea Daniel J DJ Sohal Vikaas S VS Goshen Inbal I Finkelstein Joel J Paz Jeanne T JT Stehfest Katja K Fudim Roman R Ramakrishnan Charu C Huguenard John R JR Hegemann Peter P Deisseroth Karl K
Nature 20110727 7363
Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have been hypothesized to arise from elevations in the cellular balance of excitation and inhibition (E/I balance) within neural microcircuitry. This hypothesis could unify diverse streams of pathophysiological and genetic evidence, but has not been susceptible to direct testing. Here we design and use several novel optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving ma ...[more]