Ontology highlight
ABSTRACT:
SUBMITTER: Vora SR
PROVIDER: S-EPMC4155598 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Vora Sadhna R SR Juric Dejan D Kim Nayoon N Mino-Kenudson Mari M Huynh Tiffany T Costa Carlotta C Lockerman Elizabeth L EL Pollack Sarah F SF Liu Manway M Li Xiaoyan X Lehar Joseph J Wiesmann Marion M Wartmann Markus M Chen Yan Y Cao Z Alexander ZA Pinzon-Ortiz Maria M Kim Sunkyu S Schlegel Robert R Huang Alan A Engelman Jeffrey A JA
Cancer cell 20140704 1
Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs frequently in breast cancer. However, clinical results of single-agent PI3K inhibitors have been modest to date. A combinatorial drug screen on multiple PIK3CA mutant cancers with decreased sensitivity to PI3K inhibitors revealed that combined CDK 4/6-PI3K inhibition synergistically reduces cell viability. Laboratory studies revealed that sensitive cancers suppress RB phosphorylation upon treatment with single-agent PI3K inhibitor ...[more]