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VERMONT: Visualizing mutations and their effects on protein physicochemical and topological property conservation.

ABSTRACT: In this paper, we propose an interactive visualization called VERMONT which tackles the problem of visualizing mutations and infers their possible effects on the conservation of physicochemical and topological properties in protein families. More specifically, we visualize a set of structure-based sequence alignments and integrate several structural parameters that should aid biologists in gaining insight into possible consequences of mutations. VERMONT allowed us to identify patterns of position-specific properties as well as exceptions that may help predict whether specific mutations could damage protein function.

SUBMITTER: Silveira SA

PROVIDER: S-EPMC4155615 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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VERMONT: Visualizing mutations and their effects on protein physicochemical and topological property conservation.

Silveira Sabrina A SA Fassio Alexandre V AV Gonçalves-Almeida Valdete M VM de Lima Elisa B EB Barcelos Yussif T YT Aburjaile Flávia F FF Rodrigues Laerte M LM Meira Wagner W de Melo-Minardi Raquel C RC

BMC proceedings 20140828 Suppl 2 Proceedings of the 3rd Annual Symposium on Biol

In this paper, we propose an interactive visualization called VERMONT which tackles the problem of visualizing mutations and infers their possible effects on the conservation of physicochemical and topological properties in protein families. More specifically, we visualize a set of structure-based sequence alignments and integrate several structural parameters that should aid biologists in gaining insight into possible consequences of mutations. VERMONT allowed us to identify patterns of positio ...[more]

PMID: 25237391

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