Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez ED
PROVIDER: S-EPMC4156534 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Hernandez Eloy D ED Lee Sang Jun SJ Kim Ji Young JY Duran Angeles A Linares Juan F JF Yajima Tomoko T Müller Timo D TD Tschöp Matthias H MH Smith Steven R SR Diaz-Meco Maria T MT Moscat Jorge J
Cell metabolism 20140717 3
The c-Jun NH(2)-terminal kinase (JNK) is a critical determinant of obesity-associated inflammation and glucose intolerance. The upstream mechanisms controlling this pathway are still unknown. Here we report that the levels of the PB1 domain-containing adaptor NBR1 correlated with the expression of proinflammatory molecules in adipose tissue from human patients with metabolic syndrome, suggesting that NBR1 plays a key role in adipose-tissue inflammation. We also show that NBR1 inactivation in the ...[more]