Ontology highlight
ABSTRACT:
SUBMITTER: Sha H
PROVIDER: S-EPMC4156539 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cell metabolism 20140724 3
Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum (ER)-associated degradation (ERAD), a universal quality-control system in the cell; but its physiological role remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit postprandial hypertriglyceridemia. Further analyses reveal that Sel1L is indispensable for the secretion of lipoprotein lipase (LPL), independent of its role in Hrd1-me ...[more]