Ontology highlight
ABSTRACT:
SUBMITTER: Dix AV
PROVIDER: S-EPMC4156868 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140825 35
A programmable ligand display system can be used to dissect the multivalent effects of ligand binding to a membrane receptor. An antagonist of the A2A adenosine receptor, a G-protein-coupled receptor that is a drug target for neurodegenerative conditions, was displayed in 35 different multivalent configurations, and binding to A2A was determined. A theoretical model based on statistical mechanics was developed to interpret the binding data, suggesting the importance of receptor dimers. Using thi ...[more]