Ontology highlight
ABSTRACT:
SUBMITTER: Bruns AM
PROVIDER: S-EPMC4156907 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Molecular cell 20140807 5
Cytoplasmic pattern recognition receptors detect non-self RNAs during virus infections and initiate antiviral signaling. One receptor, MDA5, possesses essential signaling domains, but weak RNA binding. A second receptor, LGP2, rapidly detects diverse dsRNA species, but lacks signaling domains. Accumulating evidence suggests LGP2 and MDA5 work together to detect viral RNA and generate a complete antiviral response, but the basis for their cooperation has been elusive. Experiments presented here a ...[more]