Increased susceptibility of beta7-integrin-deficient neonatal mice in the early stage of Cryptosporidium parvum infection.

ABSTRACT: Numerous inflammatory cells are recruited in response to Cryptosporidium parvum infection. These cells include interferon gamma-producing T lymphocytes, which are of major importance for the resolution of infection. Here, we show that beta7 integrin is not essential for the control of infection in mice but that beta7-deficient neonatal mice are more susceptible during the early stages of infection.

SUBMITTER: Mancassola R 

PROVIDER: S-EPMC415699 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature