Dataset Information

The sheep genome illuminates biology of the rumen and lipid metabolism.

ABSTRACT: Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

SUBMITTER: Jiang Y

PROVIDER: S-EPMC4157056 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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The sheep genome illuminates biology of the rumen and lipid metabolism.

Jiang Yu Y Xie Min M Chen Wenbin W Talbot Richard R Maddox Jillian F JF Faraut Thomas T Wu Chunhua C Muzny Donna M DM Li Yuxiang Y Zhang Wenguang W Stanton Jo-Ann JA Brauning Rudiger R Barris Wesley C WC Hourlier Thibaut T Aken Bronwen L BL Searle Stephen M J SMJ Adelson David L DL Bian Chao C Cam Graham R GR Chen Yulin Y Cheng Shifeng S DeSilva Udaya U Dixen Karen K Dong Yang Y Fan Guangyi G Franklin Ian R IR Fu Shaoyin S Guan Rui R Highland Margaret A MA Holder Michael E ME Huang Guodong G Ingham Aaron B AB Jhangiani Shalini N SN Kalra Divya D Kovar Christie L CL Lee Sandra L SL Liu Weiqing W Liu Xin X Lu Changxin C Lv Tian T Mathew Tittu T McWilliam Sean S Menzies Moira M Pan Shengkai S Robelin David D Servin Bertrand B Townley David D Wang Wenliang W Wei Bin B White Stephen N SN Yang Xinhua X Ye Chen C Yue Yaojing Y Zeng Peng P Zhou Qing Q Hansen Jacob B JB Kristensen Karsten K Gibbs Richard A RA Flicek Paul P Warkup Christopher C CC Jones Huw E HE Oddy V Hutton VH Nicholas Frank W FW McEwan John C JC Kijas James J Wang Jun J Worley Kim C KC Archibald Alan L AL Cockett Noelle N Xu Xun X Wang Wen W Dalrymple Brian P BP

Science (New York, N.Y.) 20140601 6188

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lip ...[more]

PMID: 24904168

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Dataset Information

The sheep genome illuminates biology of the rumen and lipid metabolism.

Publications

The sheep genome illuminates biology of the rumen and lipid metabolism.

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