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Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

ABSTRACT: We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.

SUBMITTER: Gretarsdottir S 

PROVIDER: S-EPMC4157066 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Gretarsdottir Solveig S   Baas Annette F AF   Thorleifsson Gudmar G   Holm Hilma H   den Heijer Martin M   de Vries Jean-Paul P M JP   Kranendonk Steef E SE   Zeebregts Clark J A M CJ   van Sterkenburg Steven M SM   Geelkerken Robert H RH   van Rij Andre M AM   Williams Michael J A MJ   Boll Albert P M AP   Kostic Jelena P JP   Jonasdottir Adalbjorg A   Jonasdottir Aslaug A   Walters G Bragi GB   Masson Gisli G   Sulem Patrick P   Saemundsdottir Jona J   Mouy Magali M   Magnusson Kristinn P KP   Tromp Gerard G   Elmore James R JR   Sakalihasan Natzi N   Limet Raymond R   Defraigne Jean-Olivier JO   Ferrell Robert E RE   Ronkainen Antti A   Ruigrok Ynte M YM   Wijmenga Cisca C   Grobbee Diederick E DE   Shah Svati H SH   Granger Christopher B CB   Quyyumi Arshed A AA   Vaccarino Viola V   Patel Riyaz S RS   Zafari A Maziar AM   Levey Allan I AI   Austin Harland H   Girelli Domenico D   Pignatti Pier Franco PF   Olivieri Oliviero O   Martinelli Nicola N   Malerba Giovanni G   Trabetti Elisabetta E   Becker Lewis C LC   Becker Diane M DM   Reilly Muredach P MP   Rader Daniel J DJ   Mueller Thomas T   Dieplinger Benjamin B   Haltmayer Meinhard M   Urbonavicius Sigitas S   Lindblad Bengt B   Gottsäter Anders A   Gaetani Eleonora E   Pola Roberto R   Wells Philip P   Rodger Marc M   Forgie Melissa M   Langlois Nicole N   Corral Javier J   Vicente Vicente V   Fontcuberta Jordi J   España Francisco F   Grarup Niels N   Jørgensen Torben T   Witte Daniel R DR   Hansen Torben T   Pedersen Oluf O   Aben Katja K KK   de Graaf Jacqueline J   Holewijn Suzanne S   Folkersen Lasse L   Franco-Cereceda Anders A   Eriksson Per P   Collier David A DA   Stefansson Hreinn H   Steinthorsdottir Valgerdur V   Rafnar Thorunn T   Valdimarsson Einar M EM   Magnadottir Hulda B HB   Sveinbjornsdottir Sigurlaug S   Olafsson Isleifur I   Magnusson Magnus Karl MK   Palmason Robert R   Haraldsdottir Vilhelmina V   Andersen Karl K   Onundarson Pall T PT   Thorgeirsson Gudmundur G   Kiemeney Lambertus A LA   Powell Janet T JT   Carey David J DJ   Kuivaniemi Helena H   Lindholt Jes S JS   Jones Gregory T GT   Kong Augustine A   Blankensteijn Jan D JD   Matthiasson Stefan E SE   Thorsteinsdottir Unnur U   Stefansson Kari K  

Nature genetics 20100711 8

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarc  ...[more]

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