Ontology highlight
ABSTRACT:
SUBMITTER: Gretarsdottir S
PROVIDER: S-EPMC4157066 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Gretarsdottir Solveig S Baas Annette F AF Thorleifsson Gudmar G Holm Hilma H den Heijer Martin M de Vries Jean-Paul P M JP Kranendonk Steef E SE Zeebregts Clark J A M CJ van Sterkenburg Steven M SM Geelkerken Robert H RH van Rij Andre M AM Williams Michael J A MJ Boll Albert P M AP Kostic Jelena P JP Jonasdottir Adalbjorg A Jonasdottir Aslaug A Walters G Bragi GB Masson Gisli G Sulem Patrick P Saemundsdottir Jona J Mouy Magali M Magnusson Kristinn P KP Tromp Gerard G Elmore James R JR Sakalihasan Natzi N Limet Raymond R Defraigne Jean-Olivier JO Ferrell Robert E RE Ronkainen Antti A Ruigrok Ynte M YM Wijmenga Cisca C Grobbee Diederick E DE Shah Svati H SH Granger Christopher B CB Quyyumi Arshed A AA Vaccarino Viola V Patel Riyaz S RS Zafari A Maziar AM Levey Allan I AI Austin Harland H Girelli Domenico D Pignatti Pier Franco PF Olivieri Oliviero O Martinelli Nicola N Malerba Giovanni G Trabetti Elisabetta E Becker Lewis C LC Becker Diane M DM Reilly Muredach P MP Rader Daniel J DJ Mueller Thomas T Dieplinger Benjamin B Haltmayer Meinhard M Urbonavicius Sigitas S Lindblad Bengt B Gottsäter Anders A Gaetani Eleonora E Pola Roberto R Wells Philip P Rodger Marc M Forgie Melissa M Langlois Nicole N Corral Javier J Vicente Vicente V Fontcuberta Jordi J España Francisco F Grarup Niels N Jørgensen Torben T Witte Daniel R DR Hansen Torben T Pedersen Oluf O Aben Katja K KK de Graaf Jacqueline J Holewijn Suzanne S Folkersen Lasse L Franco-Cereceda Anders A Eriksson Per P Collier David A DA Stefansson Hreinn H Steinthorsdottir Valgerdur V Rafnar Thorunn T Valdimarsson Einar M EM Magnadottir Hulda B HB Sveinbjornsdottir Sigurlaug S Olafsson Isleifur I Magnusson Magnus Karl MK Palmason Robert R Haraldsdottir Vilhelmina V Andersen Karl K Onundarson Pall T PT Thorgeirsson Gudmundur G Kiemeney Lambertus A LA Powell Janet T JT Carey David J DJ Kuivaniemi Helena H Lindholt Jes S JS Jones Gregory T GT Kong Augustine A Blankensteijn Jan D JD Matthiasson Stefan E SE Thorsteinsdottir Unnur U Stefansson Kari K
Nature genetics 20100711 8
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarc ...[more]