Effects of deuterium oxide on cell growth and vesicle speed in RBL-2H3 cells.
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ABSTRACT:
SUBMITTER: Kalkur RS
PROVIDER: S-EPMC4157235 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Effects of deuterium oxide on cell growth and vesicle speed in RBL-2H3 cells.
Kalkur Roshni S RS Ballast Andrew C AC Triplett Ashley R AR Spendier Kathrin K
PeerJ 20140902
For the first time we show the effects of deuterium oxide on cell growth and vesicle transport in rat basophilic leukemia (RBL-2H3) cells. RBL-2H3 cells cultured with 15 moles/L deuterium showed decreased cell growth which was attributed to cells not doubling their DNA content. Experimental observations also showed an increase in vesicle speed for cells cultured in deuterium oxide. This increase in vesicle speed was not observed in deuterium oxide cultures treated with a microtubule-destabilizin ...[more]
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