Ontology highlight
ABSTRACT:
SUBMITTER: Park HW
PROVIDER: S-EPMC4157315 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Park Hwan-Woo HW Park Haeli H Semple Ian A IA Jang Insook I Ro Seung-Hyun SH Kim Myungjin M Cazares Victor A VA Stuenkel Edward L EL Kim Jung-Jae JJ Kim Jeong Sig JS Lee Jun Hee JH
Nature communications 20140905
Autophagy deregulation during obesity contributes to the pathogenesis of diverse metabolic disorders. However, without understanding the molecular mechanism of obesity interference in autophagy, development of therapeutic strategies for correcting such defects in obese individuals is challenging. Here we show that a chronic increase of the cytosolic calcium concentration in hepatocytes during obesity and lipotoxicity attenuates autophagic flux by preventing the fusion between autophagosomes and ...[more]