Ontology highlight
ABSTRACT:
SUBMITTER: Boucher LE
PROVIDER: S-EPMC4157416 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Boucher Lauren E LE Bosch Jürgen J
Acta crystallographica. Section F, Structural biology communications 20140829 Pt 9
The apicomplexan parasite Toxoplasma gondii must invade host cells to continue its lifecycle. It invades different cell types using an actomyosin motor that is connected to extracellular adhesins via the bridging protein fructose-1,6-bisphosphate aldolase. During invasion, aldolase serves in the role of a structural bridging protein, as opposed to its normal enzymatic role in the glycolysis pathway. Crystal structures of the homologous Plasmodium falciparum fructose-1,6-bisphosphate aldolase hav ...[more]