Ontology highlight
ABSTRACT:
SUBMITTER: Guerra DD
PROVIDER: S-EPMC4157525 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Guerra Damian D DD Pratelli Réjane R Kraft Edward E Callis Judy J Pilot Guillaume G
FEBS letters 20130910 21
Plant LOSS OF GDU 2 (LOG2) and Mammalian Mahogunin Ring Finger 1 (MGRN1) proteins are RING-type E3 ligases sharing similarity N-terminal to the RING domain. Deletion of this region disrupts the interaction of LOG2 with the plant membrane protein GLUTAMINE DUMPER1 (GDU1). Phylogenetic analysis identified two clades of LOG2/MGRN1-like proteins in vertebrates and plants. The ability of MGRN1 to functionally replace LOG2 was tested. MGRN1 ubiquitylates GDU1 in vitro and can partially substitute for ...[more]