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IL-21 induces IL-22 production in CD4+ T cells.

ABSTRACT: Interleukin (IL)-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production by CD4+ T cells. Here we show that IL-21 triggers IL-22, but not IL-17 production by CD4+ T cells. STAT3, activated by IL-21, controls the epigenetic status of the il22 promoter and its interaction with the aryl hydrocarbon receptor (AhR). Moreover, IL-21 and AhR signalling in T cells control IL-22 production and the development of dextran sodium sulphate-induced colitis in ILC-deficient mice. Thus, we have identified IL-21 as an inducer of IL-22 production in CD4+ T cells in vitro and in vivo.

SUBMITTER: Yeste A

PROVIDER: S-EPMC4157605 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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IL-21 induces IL-22 production in CD4+ T cells.

Yeste Ada A Mascanfroni Ivan D ID Nadeau Meghan M Burns Evan J EJ Tukpah Ann-Marcia AM Santiago Andrezza A Wu Chuan C Patel Bonny B Kumar Deepak D Quintana Francisco J FJ

Nature communications 20140506

Interleukin (IL)-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production by CD4+ T cells. Here we show that IL-21 triggers IL-22, but not IL-17 production by CD4+ T cells. STAT3, activated by IL-21, controls the epigenetic status of the il22 promoter and its interaction with the aryl hydrocarbon re ...[more]

PMID: 24796415

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