Ontology highlight
ABSTRACT:
SUBMITTER: Kopf T
PROVIDER: S-EPMC4157811 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kopf Thomas T Schaefer Hans-Ludwig HL Troetzmueller Martin M Koefeler Harald H Broenstrup Mark M Konovalova Tatiana T Schmitz Gerd G
PloS one 20140908 9
Fenofibrate (FF) lowers plasma triglycerides via PPARα activation. Here, we analyzed lipidomic changes upon FF treatment of fructose fed rats. Three groups with 6 animals each were defined as control, fructose-fed and fructose-fed/FF treated. Male Wistar Unilever Rats were subjected to 10% fructose-feeding for 20 days. On day 14, fenofibrate treatment (100 mg/kg p.o.) was initiated and maintained for 7 days. Lipid species in serum were analyzed using mass spectrometry (ESI-MS/MS; LC-FT-MS, GC-MS ...[more]