Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC4157997 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Huang Yaling Y Leung Justin W C JW Lowery Megan M Matsushita Nobuko N Wang Yucai Y Shen Xi X Huong Do D Takata Minoru M Chen Junjie J Li Lei L
Cell reports 20140605 6
The Fanconi anemia (FA) core complex provides the essential E3 ligase function for spatially defined FANCD2 ubiquitination and FA pathway activation. Of the seven FA gene products forming the core complex, FANCL possesses a RING domain with demonstrated E3 ligase activity. The other six components do not have clearly defined roles. Through epistasis analyses, we identify three functional modules in the FA core complex: a catalytic module consisting of FANCL, FANCB, and FAAP100 is absolutely requ ...[more]