Ontology highlight
ABSTRACT:
SUBMITTER: Jackson KJ
PROVIDER: S-EPMC4158033 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Jackson Katherine J L KJ Liu Yi Y Roskin Krishna M KM Glanville Jacob J Hoh Ramona A RA Seo Katie K Marshall Eleanor L EL Gurley Thaddeus C TC Moody M Anthony MA Haynes Barton F BF Walter Emmanuel B EB Liao Hua-Xin HX Albrecht Randy A RA García-Sastre Adolfo A Chaparro-Riggers Javier J Rajpal Arvind A Pons Jaume J Simen Birgitte B BB Hanczaruk Bozena B Dekker Cornelia L CL Laserson Jonathan J Koller Daphne D Davis Mark M MM Fire Andrew Z AZ Boyd Scott D SD
Cell host & microbe 20140626 1
B cells produce a diverse antibody repertoire by undergoing gene rearrangements. Pathogen exposure induces the clonal expansion of B cells expressing antibodies that can bind the infectious agent. To assess human B cell responses to trivalent seasonal influenza and monovalent pandemic H1N1 vaccination, we sequenced gene rearrangements encoding the immunoglobulin heavy chain, a major determinant of epitope recognition. The magnitude of B cell clonal expansions correlates with an individual's secr ...[more]