Dataset Information

Maternal ?-hemolytic streptococcal pharyngeal exposure and colonization in pregnancy.

ABSTRACT:

Objectives

To report the pharyngeal colonization rate of ?-hemolytic streptococci and changes in the value of antistreptolysin O (ASO) and anti-DNase B serology titers during pregnancy.

Methods

Healthy pregnant women were recruited and blood was drawn in each trimester. The upper limit of normal (ULN) values for ASO and anti-DNase B was calculated for each trimester. Throat swabs were collected for culture and positive cultures were further assessed for the identification of serogroup of the isolated ?-hemolytic streptococcus.

Results

Out of a total of 126 pregnant women, 34.1% had positive throat cultures. Group C and group G strains were isolated in 18.2% of throat cultures while group F was detected in 13.5% of cases. The rate of colonization with GAS was 1.6%. There was an overall drop in ASO titer during pregnancy while anti-DNase B titers remained relatively unchanged. ULN values of 164(IU), 157(IU), and 156(IU) were calculated for ASO at the first, second, and third trimesters, respectively. Based on the ULN values, 28.6% of patients had recent streptococcal exposure.

Conclusions

These results show that pregnant women act as a reservoir for spreading potentially immunogenic (groups C and G) and disease producing (group F) virulent strains of streptococci.

SUBMITTER: Heidari-Bateni G

PROVIDER: S-EPMC4158157 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Maternal β-hemolytic streptococcal pharyngeal exposure and colonization in pregnancy.

Heidari-Bateni Giv G Brar Anoop K AK Hall Matthew M Hathcock Trupti T Epstein Deirdre D Goessling Lisa S LS Cunningham Madeleine W MW Eghtesady Pirooz P

Infectious diseases in obstetrics and gynecology 20140820

<h4>Objectives</h4>To report the pharyngeal colonization rate of β-hemolytic streptococci and changes in the value of antistreptolysin O (ASO) and anti-DNase B serology titers during pregnancy.<h4>Methods</h4>Healthy pregnant women were recruited and blood was drawn in each trimester. The upper limit of normal (ULN) values for ASO and anti-DNase B was calculated for each trimester. Throat swabs were collected for culture and positive cultures were further assessed for the identification of serog ...[more]

PMID: 25210420

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