Ontology highlight
ABSTRACT:
SUBMITTER: Makarova KS
PROVIDER: S-EPMC4158269 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Makarova Kira S KS Wolf Yuri I YI Forterre Patrick P Prangishvili David D Krupovic Mart M Koonin Eugene V EV
Extremophiles : life under extreme conditions 20140812 5
Microbial genomes encompass a sizable fraction of poorly characterized, narrowly spread fast-evolving genes. Using sensitive methods for sequences comparison and protein structure prediction, we performed a detailed comparative analysis of clusters of such genes, which we denote "dark matter islands", in archaeal genomes. The dark matter islands comprise up to 20% of archaeal genomes and show remarkable heterogeneity and diversity. Nevertheless, three classes of entities are common in these geno ...[more]