Ontology highlight
ABSTRACT:
SUBMITTER: Bahrami F
PROVIDER: S-EPMC4158428 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Bahrami Fariborz F Kukulski Filip F Lecka Joanna J Tremblay Alain A Pelletier Julie J Rockenbach Liliana L Sévigny Jean J
Mediators of inflammation 20140723
Interleukin-8 (IL-8) plays key roles in both chronic inflammatory diseases and tumor modulation. We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors. Here we investigated whether IL-8 release by intestinal epithelial HT-29 cells, a cancer cell line, is modulated by extracellular nucleotide metabolism. We first identified that HT-29 cells regulated adenosine and adenine nucleotide concentration at their surface by the expression of the ectoenzymes ...[more]