A tiered framework for risk-relevant characterization and ranking of chemical exposures: applications to the National Children's Study (NCS).

ABSTRACT: A challenge for large-scale environmental health investigations such as the National Children's Study (NCS), is characterizing exposures to multiple, co-occurring chemical agents with varying spatiotemporal concentrations and consequences modulated by biochemical, physiological, behavioral, socioeconomic, and environmental factors. Such investigations can benefit from systematic retrieval, analysis, and integration of diverse extant information on both contaminant patterns and exposure-relevant factors. This requires development, evaluation, and deployment of informatics methods that support flexible access and analysis of multiattribute data across multiple spatiotemporal scales. A new "Tiered Exposure Ranking" (TiER) framework, developed to support various aspects of risk-relevant exposu

SUBMITTER: Georgopoulos PG 

PROVIDER: S-EPMC4158851 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature