Ontology highlight
ABSTRACT:
SUBMITTER: Li T
PROVIDER: S-EPMC4159120 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Li Tun T Tian Cuiping C Scalmani Paolo P Frassoni Carolina C Mantegazza Massimo M Wang Yonghong Y Yang Mingpo M Wu Si S Shu Yousheng Y
PLoS biology 20140909 9
Action potential (AP) generation in inhibitory interneurons is critical for cortical excitation-inhibition balance and information processing. However, it remains unclear what determines AP initiation in different interneurons. We focused on two predominant interneuron types in neocortex: parvalbumin (PV)- and somatostatin (SST)-expressing neurons. Patch-clamp recording from mouse prefrontal cortical slices showed that axonal but not somatic Na+ channels exhibit different voltage-dependent prope ...[more]