Genetic influences on the development of alcoholism.
Ontology highlight
ABSTRACT:
SUBMITTER: Enoch MA
PROVIDER: S-EPMC4159132 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Genetic influences on the development of alcoholism.
Current psychiatry reports 20131101 11
Alcoholism has a substantial heritability yet the detection of specific genetic influences has largely proved elusive. The strongest findings are with genes encoding alcohol metabolizing enzymes. A few candidate genes such as GABRA2 have shown robust associations with alcoholism. Moreover, it has become apparent that variants in stress-related genes such as CRHR1, may only confer risk in individuals exposed to trauma, particularly in early life. Over the past decade there have been tremendous ad ...[more]
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