Ontology highlight
ABSTRACT:
SUBMITTER: Malinovsky Y
PROVIDER: S-EPMC4159259 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Malinovsky Yaakov Y Albert Paul S PS Schisterman Enrique F EF
Biometrics 20111009 1
Due to the rising cost of laboratory assays, it has become increasingly common in epidemiological studies to pool biospecimens. This is particularly true in longitudinal studies, where the cost of performing multiple assays over time can be prohibitive. In this article, we consider the problem of estimating the parameters of a Gaussian random effects model when the repeated outcome is subject to pooling. We consider different pooling designs for the efficient maximum likelihood estimation of var ...[more]