Ontology highlight
ABSTRACT:
SUBMITTER: Lagona F
PROVIDER: S-EPMC4159441 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Lagona Francesco F Jdanov Dmitri D Shkolnikova Maria M
Statistics in medicine 20140602 23
Longitudinal data are often segmented by unobserved time-varying factors, which introduce latent heterogeneity at the observation level, in addition to heterogeneity across subjects. We account for this latent structure by a linear mixed hidden Markov model. It integrates subject-specific random effects and Markovian sequences of time-varying effects in the linear predictor. We propose an expectationŰ-maximization algorithm for maximum likelihood estimation, based on data augmentation. It reduce ...[more]