Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh AK
PROVIDER: S-EPMC4159447 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Ghosh Arun K AK Osswald Heather L HL
Chemical Society reviews 20141001 19
BACE1 (β-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's disease. BACE1 is an aspartic protease which functions in the first step of the pathway leading to the production and deposition of amyloid-β peptide (Aβ). Its gene deletion showed only mild phenotypes. BACE1 inhibition has direct implications in the Alzheimer's disease pathology without largely affecting viability. However, inhibiting BACE1 selectively in vivo has presented many challenges t ...[more]