Ontology highlight
ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC4159602 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Wu Zheng Z Guo Ziyuan Z Gearing Marla M Chen Gong G
Nature communications 20140613
Amyloid plaques and tau tangles are common pathological hallmarks for Alzheimer's disease (AD); however, reducing Aβ production failed to relieve the symptoms of AD patients. Here we report a high GABA (γ-aminobutyric acid) content in reactive astrocytes in the dentate gyrus (DG) of a mouse model for AD (5xFAD) that results in increased tonic inhibition and memory deficit. We also confirm in human AD patient brains that dentate astrocytes have a high GABA content, suggesting that high astrocytic ...[more]