Ontology highlight
ABSTRACT:
SUBMITTER: Carty SA
PROVIDER: S-EPMC4160212 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Carty Shannon A SA Koretzky Gary A GA Jordan Martha S MS
PloS one 20140910 9
Interleukin (IL)-4 is a cytokine classically associated with CD4(+) T helper type 2 differentiation, but has been recently shown to also be required for the development of CD8(+) innate-like lymphocytes. CD8(+) innate-like lymphocytes are non-conventional lymphocytes that exhibit characteristics typically associated with memory CD8(+) T cells, including expression of the T-box transcription factor Eomesodermin (Eomes). Here we investigate the signaling pathways required for IL-4 induction of Eom ...[more]