Ontology highlight
ABSTRACT:
SUBMITTER: Davis CF
PROVIDER: S-EPMC4160352 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cancer cell 20140821 3
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting a ...[more]