Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.
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ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC4160381 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.
Dong Yizhou Y Eltoukhy Ahmed A AA Alabi Christopher A CA Khan Omar F OF Veiseh Omid O Dorkin J Robert JR Sirirungruang Sasilada S Yin Hao H Tang Benjamin C BC Pelet Jeisa M JM Chen Delai D Gu Zhen Z Xue Yuan Y Langer Robert R Anderson Daniel G DG
Advanced healthcare materials 20140313 9
New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo. ...[more]
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