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A Novel Therapeutic Agent for Type 2 Diabetes Mellitus: SGLT2 Inhibitor.


ABSTRACT: Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic disorder, and a major public health problem that is rapidly increasing in prevalence. Although a wide range of pharmacotherapies for glycemic control is now available, management of T2DM remains complex and challenging. The kidneys contribute immensely to glucose homeostasis by reabsorbing glucose from the glomerular filtrate. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a new class of antidiabetic agents that inhibit glucose absorption from the kidney independent of insulin, offer a unique opportunity to improve the outcomes of patients with T2DM. In this review, we provide an overview of two globally-approved SGLT2 inhibitors, dapagliflozin and canagliflozin, and discuss their effects and safety. This information will help clinicians to decide whether these drugs will benefit their patients.

SUBMITTER: Jung CH 

PROVIDER: S-EPMC4160579 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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A Novel Therapeutic Agent for Type 2 Diabetes Mellitus: SGLT2 Inhibitor.

Jung Chang Hee CH   Jang Jung Eun JE   Park Joong-Yeol JY  

Diabetes & metabolism journal 20140801 4


Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic disorder, and a major public health problem that is rapidly increasing in prevalence. Although a wide range of pharmacotherapies for glycemic control is now available, management of T2DM remains complex and challenging. The kidneys contribute immensely to glucose homeostasis by reabsorbing glucose from the glomerular filtrate. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a new class of antidiabetic agents that inhibit glu  ...[more]

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