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Design and characterization of 3-Azidothalidomide as a selective hydrogen sulfide probe.


ABSTRACT: Hydrogen sulfide (H2S) has been recently recognized as an important signaling molecule in biological systems. Herein, we report the development of a fluorescence turn-on probe based on the structure of pomalidomide, a FDA approved drug for the treatment of multiple myeloma. Various characterizations demonstrated high selectivity and sensitivity of this probe towards H2S. Furthermore, the application of this probe to detect H2S in living cells was confirmed by flow cytometry and fluorescence imaging studies.

SUBMITTER: Liu K 

PROVIDER: S-EPMC4160736 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Design and characterization of 3-Azidothalidomide as a selective hydrogen sulfide probe.

Liu Kai K   Zhang Shijun S  

Tetrahedron letters 20141001 40


Hydrogen sulfide (H<sub>2</sub>S) has been recently recognized as an important signaling molecule in biological systems. Herein, we report the development of a fluorescence turn-on probe based on the structure of pomalidomide, a FDA approved drug for the treatment of multiple myeloma. Various characterizations demonstrated high selectivity and sensitivity of this probe towards H<sub>2</sub>S. Furthermore, the application of this probe to detect H<sub>2</sub>S in living cells was confirmed by flo  ...[more]

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