SANTA: quantifying the functional content of molecular networks.
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ABSTRACT:
SUBMITTER: Cornish AJ
PROVIDER: S-EPMC4161294 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
SANTA: quantifying the functional content of molecular networks.
Cornish Alex J AJ Markowetz Florian F
PLoS computational biology 20140911 9
Linking networks of molecular interactions to cellular functions and phenotypes is a key goal in systems biology. Here, we adapt concepts of spatial statistics to assess the functional content of molecular networks. Based on the guilt-by-association principle, our approach (called SANTA) quantifies the strength of association between a gene set and a network, and functionally annotates molecular networks like other enrichment methods annotate lists of genes. As a general association measure, SAN ...[more]
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