Ontology highlight
ABSTRACT:
SUBMITTER: Luo W
PROVIDER: S-EPMC4161513 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20140730 18
Actin filaments play an essential role in cell movement, and many posttranslational modifications regulate actin filament assembly. Here we report that prolyl hydroxylase 3 (PHD3) interacts with nonmuscle actin in human cells and catalyzes hydroxylation of actin at proline residues 307 and 322. Blocking PHD3 expression or catalytic activity by short hairpin RNA knockdown or pharmacological inhibition, respectively, decreased actin prolyl hydroxylation. PHD3 knockdown increased filamentous F-acti ...[more]