High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients.

ABSTRACT: Although several single-nucleotide polymorphisms in microRNA (miRNA) genes have been associated with primary hepatocellular carcinoma, published findings regarding this relationship are inconsistent and inconclusive.The high-resolution melting (HRM) analysis was used to determine whether the occurrence of the SNPs of miR-146a C?>?G (rs2910164), miR-196a2 C?>?T (rs11614913), miR-301b A?>?G (rs384262), and miR-499 C?>?T (rs3746444) differs in frequency-matched 314 HCC patients and 407 controls by age and sex.The groups' genotype distributions of miR-196a2 C?>?T and miR-499 C?>?T differed significantly (P??T was significantly different between the two groups, and the HCC risk of carriers of the C allele was higher than that of carriers of the T allele (odds ratio, 1.53; 95% CI, 1.15-2.03; P?=?0.003). Further, we found that the activated partial thromboplastin time (APTT) in HCC patients with miR-196a2 CC genotype was longer than patients with TT genotypes (P??T and miR-499 C?>?T confer HCC risk and that affect the clinical laboratory characteristics of HCC patients.

SUBMITTER: Qi JH 

PROVIDER: S-EPMC4161871 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature