Ontology highlight
ABSTRACT:
SUBMITTER: Iscla I
PROVIDER: S-EPMC4161981 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Iscla Irene I Wray Robin R Wei Shuguang S Posner Bruce B Blount Paul P
Nature communications 20140910
The antibiotic streptomycin is widely used in the treatment of microbial infections. The primary mechanism of action is inhibition of translation by binding to the ribosome, but how it enters the bacterial cell is unclear. Early in the study of this antibiotic, a mysterious streptomycin-induced potassium efflux preceding any decrease in viability was observed; it was speculated that this changed the electrochemical gradient such that streptomycin better accessed the cytoplasm. Here we use a high ...[more]