Ontology highlight
ABSTRACT:
SUBMITTER: Ye X
PROVIDER: S-EPMC4163864 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Ye Xingming X Bai Wendong W Zhu Huayu H Zhang Xiao X Chen Ying Y Wang Lei L Yang Angang A Zhao Jing J Jia Lintao L
BMB reports 20140501 5
HER2-overexpressing breast cancers are characterized by frequent distant metastasis and often develop resistance after short-term effective treatment with the monoclonal antibody drug, trastuzumab. Here, we found that the oncogenic miRNA, miR-221, inhibited apoptosis, induced trastuzumab resistance and promoted metastasis of HER2-positive breast cancers. The tumor suppressor PTEN was identified as a miR-221 target; overexpression of PTEN abrogated the aforementioned miR-221-induced malignant phe ...[more]