Ontology highlight
ABSTRACT:
SUBMITTER: Atwood BK
PROVIDER: S-EPMC4163916 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nature neuroscience 20140223 4
As prescription opioid analgesic abuse rates rise, so does the need to understand the long-term effects of opioid exposure on brain function. The dorsal striatum is an important site for drug-induced neuronal plasticity. We found that exogenously applied and endogenously released opioids induced long-term depression (OP-LTD) of excitatory inputs to the dorsal striatum in mice and rats. Mu and delta OP-LTD, although both being presynaptically expressed, were dissociable in that they summated, dif ...[more]