Ontology highlight
ABSTRACT:
SUBMITTER: Donia MS
PROVIDER: S-EPMC4164201 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Donia Mohamed S MS Cimermancic Peter P Schulze Christopher J CJ Wieland Brown Laura C LC Martin John J Mitreva Makedonka M Clardy Jon J Linington Roger G RG Fischbach Michael A MA
Cell 20140901 6
In complex biological systems, small molecules often mediate microbe-microbe and microbe-host interactions. Using a systematic approach, we identified 3,118 small-molecule biosynthetic gene clusters (BGCs) in genomes of human-associated bacteria and studied their representation in 752 metagenomic samples from the NIH Human Microbiome Project. Remarkably, we discovered that BGCs for a class of antibiotics in clinical trials, thiopeptides, are widely distributed in genomes and metagenomes of the h ...[more]