Ontology highlight
ABSTRACT:
SUBMITTER: Sarosiek KA
PROVIDER: S-EPMC4164233 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Sarosiek Kristopher A KA Chi Xiaoke X Bachman John A JA Sims Joshua J JJ Montero Joan J Patel Luv L Flanagan Annabelle A Andrews David W DW Sorger Peter P Letai Anthony A
Molecular cell 20130901 6
Apoptosis is a highly regulated form of cell death that controls normal homeostasis as well as the antitumor activity of many chemotherapeutic agents. Commitment to death via the mitochondrial apoptotic pathway requires activation of the mitochondrial pore-forming proteins BAK or BAX. Activation can be effected by the activator BH3-only proteins BID or BIM, which have been considered to be functionally redundant in this role. Herein, we show that significant activation preferences exist between ...[more]