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The distribution of implant fixation for femoral components of TKA: a postmortem retrieval study.

ABSTRACT: Aseptic loosening of total knee arthroplasty (TKA) components is the foremost cause of implant failure in the long term. While tibial component loosening is of primary concern, femoral loosening may become a clinical problem due to younger, more active patients seeking TKA, and also high-flexion designs. In this study, we analyzed the fixation for 19 non-revised, postmortem retrieved, femoral components of TKA with time in service ranging from 1 to 22 years. We found that the average total contact fraction for cemented components was 9.5% and had a power law response (decrease) with years in service. The average initial interdigitation depth was 0.7mm, and the average current interdigitation depth was 0.13mm. Loss of interdigitation was 81%. Over all, minimal fixation seems necessary for long-term success of TKA femoral components.

SUBMITTER: Howard KI

PROVIDER: S-EPMC4164597 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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The distribution of implant fixation for femoral components of TKA: a postmortem retrieval study.

Howard Karen I KI Miller Mark A MA Damron Timothy A TA Mann Kenneth A KA

The Journal of arthroplasty 20140418 9

Aseptic loosening of total knee arthroplasty (TKA) components is the foremost cause of implant failure in the long term. While tibial component loosening is of primary concern, femoral loosening may become a clinical problem due to younger, more active patients seeking TKA, and also high-flexion designs. In this study, we analyzed the fixation for 19 non-revised, postmortem retrieved, femoral components of TKA with time in service ranging from 1 to 22 years. We found that the average total conta ...[more]

PMID: 24845717

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Peri-implant bone strains and micro-motion following in vivo service: a postmortem retrieval study of 22 tibial components from total knee replacements.

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| S-EPMC4100998 | biostudies-literature

Less invasive TKA: extramedullary femoral reference without navigation.

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Rat diaphyseal femoral fracture healing: Plate fixation vs. intramedullary nail

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2005-01-01 | GSE1685 | GEO

Implant fracture of the TFNA femoral nail.

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| S-EPMC8473538 | biostudies-literature

Arthrodesis After Infected Revision TKA: Retrospective Comparison of Intramedullary Nailing and External Fixation.

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Cementless femoral prostheses cost more to implant than cemented femoral prostheses.

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Systemic distribution of West Nile virus infection: postmortem immunohistochemical study of six cases.

Project description:Rare cases of West Nile virus (WNV)-associated inflammation outside the central nervous system (CNS) have been reported. We evaluated the systemic distribution of WNV in postmortem tissues during encephalitis in six patients using immunohistochemistry. WNV antigens were detected in neurons of CNS (all 6 cases), kidney (4 cases), lungs (2 cases), pancreas (2 cases), thyroid (2 cases), intestine (2 cases), stomach (1 case), esophagus (1 case), bile duct (1 case), skin (1 case), prostate (1 case) and testis (1 case). In systemic organs epithelial cells were infected. In none of the six cases were viral antigens identified in hepatocytes, heart, adrenal gland, nerves, skeletal muscles, bone, vessels and fat. All cases in which viral antigens were identified in systemic organs in addition to CNS were severely immunocompromised transplant recipients. With the exception of testis and brain, most foci of infection were not associated with inflammation. While the absence of inflammation may in part be due to patient immunosuppression or to possible transient nature of any host response, compartmentalization of viral antigen to the luminal region of epithelial cells may sequester WNV from immune recognition. Comparison of our findings with previous reports suggests that patients with WNV encephalitis can have widespread systemic infection.

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