Orthologous gene-expression profiling in multi-species models: search for candidate genes.
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ABSTRACT:
SUBMITTER: Grigoryev DN
PROVIDER: S-EPMC416470 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Publications
Orthologous gene-expression profiling in multi-species models: search for candidate genes.
Grigoryev Dmitry N DN Ma Shwu-Fan SF Irizarry Rafael A RA Ye Shui Qing SQ Quackenbush John J Garcia Joe G N JG
Genome biology 20040427 5
Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biologic ...[more]
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