Ontology highlight
ABSTRACT:
SUBMITTER: Mirsafian H
PROVIDER: S-EPMC4164807 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mirsafian Hoda H Mat Ripen Adiratna A Merican Amir Feisal AF Bin Mohamad Saharuddin S
TheScientificWorldJournal 20140828
Beta-amyloid precursor protein cleavage enzyme 1 (BACE1) and beta-amyloid precursor protein cleavage enzyme 2 (BACE2), members of aspartyl protease family, are close homologues and have high similarity in their protein crystal structures. However, their enzymatic properties differ leading to disparate clinical consequences. In order to identify the residues that are responsible for such differences, we used evolutionary trace (ET) method to compare the amino acid conservation patterns of BACE1 a ...[more]