Ontology highlight
ABSTRACT:
SUBMITTER: Villarreal G
PROVIDER: S-EPMC4165389 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Villarreal Guadalupe G Zhang Yuzhi Y Larman H Benjamin HB Gracia-Sancho Jorge J Koo Andrew A García-Cardeña Guillermo G
Biochemical and biophysical research communications 20091205 1
The Kruppel-like factor 2 (KLF2) and Kruppel-like factor 4 (KLF4) transcription factors have recently been shown to act as critical regulators of endothelial homeostasis. While several insights have been made into the signaling mechanisms orchestrating endothelial KLF2 expression, those governing the expression of KLF4 in the vascular endothelium remain largely unknown. Here, we show that diverse vasoprotective stimuli including an atheroprotective shear stress waveform, simvastatin, and resvera ...[more]